Reparto y equipo

Sam Raimi

Tobey Maguire Spider-Man / Peter Parker

Kirsten Dunst Mary Jane Watson

James Franco Harry Osborn

Alfred Molina Doc Ock / Otto Octavius

Rosemary Harris May Parker

J.K. Simmons J. Jonah Jameson

Donna Murphy Rosalie Octavius

Daniel Gillies John Jameson

Dylan Baker Dr. Curt Connors

Bill Nunn Joseph 'Robbie' Robertson

Vanessa Ferlito Louise

Aasif Mandvi Mr. Aziz

Willem Dafoe Green Goblin / Norman Osborn

Cliff Robertson Ben Parker

Ted Raimi Hoffman

Avi Arad

Lorne Orleans

Laura Ziskin

Danny Elfman

Bill Pope

Bob Murawski